Behavioral and subjective effects of D-amphetamine and modafinil in healthy adults.

Modafinil is indicated for the management of excessive daytime sleepiness; however, recent studies have examined a broad range of potential uses. Given that clinical uses of modafinil may be expanding, this study compared modafinil and d-amphetamine effects on subjective and performance measures. Across 11 sessions, 11 healthy adults were tested after oral doses of placebo (5 sessions), modafinil (1.75 mg/kg, 3.50 mg/kg, or 7.00 mg/kg), and d-amphetamine (0.035 mg/kg, 0.070 mg/kg, 0.140 mg/kg) under double-blind, randomized conditions. Assessments of cognitive performance and subjective effects were completed before drug administration, 30 min after drug administration, and at hourly intervals after drug administration for 5 hr. Modafinil increased ratings on the Amphetamine and Morphine Benzedrine Group scales of the Addiction Research Center Inventory (ARCI) and increased ratings on the Vigor and Total Positive scales of the Profile of Mood States. d-Amphetamine increased visual analog ratings of feeling stimulated and liking the drug and increased ratings on the Morphine Benzedrine Group scale of the ARCI. Both medications significantly reduced visual analog scale ratings of feeling sleepy, and modafinil decreased ratings on the ARCI Pentobarbital-Chlorpromazine-Alcohol Group scale. Both medications sustained performance that deteriorated across time on the Sternberg Number Recognition Test. Modafinil also enhanced performance rate on the Digit-Symbol Substitution Task above baseline levels and increased response rate on the Repeated Acquisition of Response Sequences Task. These results suggest that modafinil engenders alerting effects and increases performance in healthy non-sleep-deprived individuals comparable with that of d-amphetamine. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Symmetric BEM formulations for 2-D steady-state and transit potential problems

This paper presents a new concept for symmetric boundary element method (SBEM) applicable to 2-D steady-state and transit potential problems. Two kinds of SBEM formulations are derived. Symmetry is obtained simply through matrix manipulation, and no hypersingularity appears. Therefore, SBEM is much easier than the traditional symmetric Galerkin BEM. Compared with the traditional asymmetric BEM, the present SBEM can reduce the computational cost for time domain problems only. However, when applied to BEM/FEM coupling procedure, SBEM can reduce the computational cost for both steady-state and time domain problems. Three numerical examples are included to illustrate the effectiveness and accuracy of the present formulations.     

A BOUNDARY INTEGRAL EQUATION AND ITS NUMERICAL SOLUTION OF POTENTIAL FLOW AROUND SURFACE-IRREGULA-RITIES

In this paper,using complex functional theory,the authors turn the potentialflow around the surface irregularities in a pressure conduit and semi-infinite platforms intoDirichlet problem.Based on Schwarz formula and by the application of Plemelj's formula,theauthors change the problem into the integration of a Cauchy boundary integral equation in theflow plane through the substitution of variables.Using numerical integration,the authors obtainthe velocity distribution and pressure coefficient along surface irregularities and platforms.Thephysical concept of this method is clear,the convergent speed is rapid and the computative effi-ciency is high.The calculated values agree well with the measured results.It is an effective andsimple method in solving potential flow.     

环境因素对碳钢点蚀临界电势的影响

采用动电势扫描法测定了不同体系中碳钢发生点蚀的临界电势Eb。结果表明 :当Cl- 浓度 <0 .0 1mol/L时 ,随Cl- 浓度增加 ,临界电势负移并与Cl- 浓度成线性关系 ;pH值在 7～ 11之间 ,随pH值增加 ,临界电势正移并与pH值成线性关系 ;随温度增加 ,临界电势负移并与温度成线性关系。     

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解决注水泥作业的防气窜问题，是提高固井质量，保护油气层的关键技术。现有预测和防止水泥浆气管理的方法虽然较多，但应用于现场却有一定困难，主要表现在所考虑的因素比较单一，有些高温、高压下的水泥浆性能参数难以测定。文章在分析国内外预测和防止气窜方法的基础上，应用水泥浆浆体在环空的组成，GFP系数、水泥浆稠度阻力系数（A）及多凝水泥和环空加压等措施，拟定出一套提高水泥浆顶替效率，保证水泥浆动态和静态过程压力平衡关系的具体设计方法。     

轴对称问题线元上分布奇点的诱导速度势和诱导速度

本文给出轴对称问题线元上高次分布源和偶极在无界域中的诱导速度势和诱导速度的计算公式,可供用分布奇点法求解轴对称势流问题时参考.     

山前平原地下水侧向补给潜力空间变异模拟

SWAT模型利用分辨率较高的DEM数据,可以估算山前地下水侧向补给的空间变异,并可以计算不同降水年型下补给量的差别。模拟需要对研究区进行填洼、流向确定、汇流和河网水系的提取四步运算,并对河道临界支撑面积的取值进行分析。分别模拟了平水年和丰水年两种降雨年型下研究区13个出水口的地下水侧向补给潜力。在研究区,由于地形的变化,导致山与平原交接断面上出水口的集水面积变异非常大,因此山前平原所接受的地下水侧向补给量的空间变异也非常大。不同的降雨年型下,降雨量转化为地下水侧向补给量的比例也不同。平水年的转化比例较小,丰水年的转化比例较大。应用SWAT模型时,与ArcView的拓展模块有机结合,可以更方便提取完整的大流域,划分出合理的子流域。     

准噶尔盆地三台-北三台地区第三系勘探潜力分析

从沉积及储层组合、油气运移系统等方面全面剖析了准噶尔盆地三台-北三台地区第三系油气成藏条件，建立了成藏模式，对未钻探区勘探潜力进行了预测；通过分析，认为该区第三系储层物性主体差，断裂更多地表现为封闭性，导致沟通深部油气源的运移体系不畅，致使第三系圈闭不能有效捕获和储集油气。圈闭又比较匮乏，主体勘探潜力不大。北25井西背斜紧邻多期活动的甘诃子北断裂，第三系可能发育较好的储层，相对有利，北25井西背斜应是钻探第三系的首选目标。     

On the Locus of Speed-Accuracy Trade-Off in Reaction Time: Inferences From the Lateralized Readiness Potential.

Lateralized readiness potentials (LRPs) were used to determine the stage(s) of reaction time (RT) responsible for speed-accuracy trade-offs (SATs). Speeded decisions based on several types of information were examined in 3 experiments, involving, respectively, a line discrimination task, lexical decisions, and an Erikson flanker task. Three levels of SAT were obtained in each experiment by adjusting response deadlines with an adaptive tracking algorithm. Speed stress affected the duration of RT stages both before and after the start of the LRP in all experiments. The latter effect cannot be explained by guessing strategies, by variations in response force, or as an indirect consequence of the pre-LRP effect. Contrary to most models, it suggests that SAT can occur at a late postdecisional stage. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of functionalization and boron and nitrogen substitution on some properties of carbon nanotubes

Molecular orbital calculations of the ionization potential of single wall carbon nanotubes having donor NH₂ and acceptor NO₂ groups bonded to the side walls and ends and boron and nitrogen substituted for carbon show substantial increases in ionization potential compared to carbon nanotubes with no functional groups and no carbon substitutions. The presence of a carbon vacancy on the side wall also causes a substantial increase in the ionization potential. The effect of tube length on the ionization energy is also calculated. The calculations also suggest that at appropriate levels of boron and nitrogen doping the armchair carbon nanotubes could be high temperature organic ferromagnetic materials.